| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Peptidomimetics are synthetic small molecules engineered to replicate the structure and function of peptides. While peptides offer advantages like superior binding affinity, selectivity, and low toxicity, their limited bioavailability, metabolic stability, and high cost hinder their representation in the pharmaceutical market. Peptidomimetics, truncated versions of peptides retaining minimum active sequences (MAS), emerge from detailed structure-activity relationship (SAR) exploration, including changes to backbone structures, side-chain modifications, use of unnatural amino acids or incorporation of non-peptide elements. This process transforms the bioactive sequence into a more drug-like compound, making them valuable in drug design and development. Approved peptidomimetic drugs, such as Nirmatrelvir, Bortezomib, Ximelagatran, Atazanavir, and Saquinavir, exhibit properties akin to small molecule drugs, including oral bioavailability, cell penetration, and favorable pharmacokinetics (PK).
A peptidomimetic is a small protein-like chain designed to mimic a peptide. They typically arise from modification of an existing peptide in order to alter the molecule's properties. For example, they may arise from modifications to change the molecule's stability or biological activity. This can have a role in the development of drug-like compounds from existing peptides. These modifications involve changes to the peptide that will not occur naturally (such as altered backbones and the incorporation of nonnatural amino acids).
An example of peptidomimetics were those designed and synthesized with the purpose of binding to target proteins in order to induce cancer cells into a form of programmed cell death called apoptosis. Basically, these work by mimicking key interactions that activate apoptotic pathway in the cell.
All healthy cells in metazoa (multi-celled animals) are subject to programmed cell death when they are no longer wanted; but cancer cells have the ability to evade apoptosis and the body's attempts to get rid of them. So peptidomimetics are part of the wide effort by researchers, research labs and institutions to create cures for cancer by means of restoring or activating apoptotic pathways in specific cells.
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Shanghai Lonwin Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals.
We could give you:
1.Best quality in your requirement
2.Competitive price in China market
3.Mature Technical support
4.Professional logistic support
All we want is win-win business. Send yr. inquiries, you will get it!
Storage:
keep container tightly closed in a dry and well-ventilated place.
Packing:25kgs/bag or 25kgs/drum
| Weight | Packing |
| <25KG | By foil-alum bag/pap/bottle |
| ≥25kg | Package: 25kg/drum/bag or as your request |
Lonwin Chemical Industry Group is a company committed to the contract synthesis and production of Medicine Polypeptide, Beauty Polypeptide, Customized Polypeptide, and APIs. Our company holds ISO and REACH international certifications. We have OEM processing plants with decades of cooperation in Jiangsu, Anhui, and other regions, providing a more solid foundation for the customized production services of special chemicals.Currently, our products are widely sold in North America, Europe, Japan, South Korea, and the Middle East. Customers are highly satisfied with both our products and services.
To achieve sustainable and stable development, we have established close cooperative relationships with renowned universities and institutions in China. We regularly exchange information with them and collaborate on new technology R&D.Adhering to the business philosophy of "quality first, credit first, service first, creativity first", we are striving to meet the demands of customers worldwide. We sincerely welcome your visit and business cooperation and look forward to working with you to expand the international market together!
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